The emergence of new strains of SARS-CoV-2. What does it mean for COVID-19 vaccines

June 1, 2021 by Immunise - a PI India Initiative Resources

This experts review article is based on various studies on the effectiveness of existing covid vaccines against new strains.

URL	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074646/
Date of publication	April 25, 2021,NIH
Category:	Vaccine Effectiveness
Study Design
Country of Study
Level of Evidence	Level V Therapeutic studies: Expert Review
Aim/ Question studied	This experts review article is based on various studies on the effectiveness of existing covid vaccines against new strains.
Study done / What did they do?
Results
Conclusion
Summary	Brazilian P.1, UK B.1.1.7, and South African 1.351 mutations are dangerous because they avoid detection by the immune system, bind strongly to the ACE2 receptor, and may cause additional harm. In a nutshell, an expert review based on research on various vaccines against new strains was conducted, and the findings revealed that BioNTech-Pfizer was effective against Brazil strains but slightly less effective against the UK and African strains. Astra Zeneca-University of Oxford was effective against strains from the United Kingdom and Brazil, but not those from South Africa. Against the UK strain, both the Indian vaccine (Covaxin) and the Moderna vaccine (mRNA-1273) were effective. There is no specific data available for Brazil, South Africa, New York, and California strain. In contrast, the Johnson & Johnson Vaccine (Ad26.COV2.S) is effective against variants found in the United Kingdom, Brazil, and South Africa.

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